Studies show that men’s testosterone levels have been declining for decades. The most prominent, a 2007 study in the Journal of Clinical Endocrinology and Metabolism, revealed a “substantial” drop in U.S. men’s testosterone levels since the 1980s, with average levels declining by about 1% per year. Testosterone levels affect women as well. However, women create lower levels and are more sensitive to androgens than men.
Over the years, I have dedicated much time working with prescribers, pharmacists and other leading health care providers throughout the United States in the field of hormone replacement therapy (HRT). I even created an online platform www.hormonesandme.com to assist patients and providers in getting on the right HRT protocol.
As a pharmacist, one question every patient considering HRT always asks me “Is there something natural I can try before we start HRT?” I did market research on several products and while there were a few good ones, I could never recommend something whole heartedly. There was always some setback. So, I set out on a journey to create a product that had scientific evidence behind its ingredients and one that was transparent in its contents. As a compounding pharmacist constantly checking for active ingredients in medications I got sick and tired of seeing those formulas with “PROPREITARY BLENDS” that never tell you exactly what you’re getting! That’s how Alpha Male X and Alpha Female were born.
What makes Alpha Male X and Alpha Female different?
To understand this. We need to know what Sex Hormone Binding Globulin (SHBG) is and how it reacts to STRESS.
First let’s talk a little about stress and why The Alpha Male X is uniquely formulated. Stress is our reaction to our external, as well as our internal environment such as pain, inflammation, even thoughts and feelings. Stress is our body's natural response to dangers, commonly known as our "fight or flight" mechanism. This response involves a complex biochemical/hormonal process, including our stress hormone cortisol. Cortisol has an inverse relationship with our sex hormones such as testosterone, estrogen, progesterone etc. When we are under stress mother nature decides that it’s not time to breed, it’s time to fight or take flight.
In our body we have free hormones and bound hormones. Think of hormones as keys, and the hormone receptors on the cell, as locks. We need the keys to fit into the locks to trigger a positive response.
When we are under chronic stress, our body produces more SHBG which binds up the FREE testosterone. Only those hormones that are FREE can fit in the lock and do what it needs to do. So, symptoms of low T do not necessarily mean you have low testosterone,but rather too little free testosterone and too much bound testosterone, that is not usable.
HIGH Cortisol → HIGH SHBG → LOW Free T → Symptoms of testosterone deficiency.
Unfortunately, classic medicine seems to focus on the fact that the SHBG, which can either be high or low, is not pertinent, that the total testosterone is ALL THATMATTERS. It is the FREE testosterone that REALLY MATTERS, and FREE T is what will affect one’s symptoms!
What is not recognized is that variations in the circulating levels of this high-affinity steroid-binding protein has tremendous effects on how one feels and the amount of BIOAVAILABLE OR FREE Testosterone that is available.
This is why we’re the only Free Testosterone boosting product on the market that concentrates on reducing cortisol by using an adaptogen such as Ashwagandha and then focusing on ingredients that lower SHBG and FREE up Testosterone to do it’s work in your body.
Alpha Male X vs Alpha Female
Because of the marked difference in the total and free testosterone in women and men, a slight increase in SHBG in a woman will decrease her free testosterone. The total may be normal but the free very low. As a result, physicians tend to say that because of the normal total testosterone that the woman need not be treated, which is not true because of the low free testosterone. Alpha Female is designed to address this issue.
Richard Harris MD, PharmD
Chief Medical Officer, Alpha Therapeutics
Jobby John, PharmD, FACA
Founder, Alpha Therapeutics